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目的测定胃必舒胶囊中胡椒碱的含量。OBJECTIVE To determine the content of piperine in weibishu capsule by RP-HPLC.
本文就胡椒碱提高药物生物利用度的机制进行综述。In this article, we summarized the advances on mechanism of how Piperine enhance the bioavailability of drugs.
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峰面积外标法同时测定姜黄胶囊中姜黄素和胡椒碱的含量。External standard method was used for simultaneous determination of both curcumin and piperine in turmeric capsule.
结论N-甲基-2-吡咯烷酮为荜茇提取物中胡椒碱经皮给药有效的渗透促进剂。Conclusion N-methyl-2-pyrrolidone is an effective transdermal delivery enhancers for piperine in Extractum Piperis Longi.
这为将来评价胡椒碱及其衍生物治疗白癜风的新疗法提供了依据。This provides support for the future clinical evaluation of piperine and its derivatives as novel treatments for vitiligo.
目的研究胡椒碱对动物睡眠的影响及其抗惊厥作用。OBJECTIVE To study the effects of piperine on sleep in mice and rabbits, and analyse anticonvulsant action of piperine in mice.
胡椒碱可以提高药物的生物利用度，增强临床疗效。Several studies have reported the enhancement of bioavailability and improvement of therapeutics of drugs when coadministered with Piperine.
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研究小组在小鼠皮肤上比较了单独应用胡椒碱及其衍生物和放射治疗后使用胡椒碱及其衍生物的效果。The team compared the effects of piperine and its derivatives when applied to the skin of mice either alone or followed by radiation treatment.
结论胡椒碱延长家兔的深睡眠和抗惊厥作用可能与其增加脑内5-羟色胺含量有关。CONCLUSION Piperine can prolong the deep sleep of rabbits, and has more strong anticonvulsant action. The mechanism of action may be related to increase of 5-HT in brain.
结果胡椒碱可明显减少小鼠的自主活动，并明显的延长戊巴比妥钠诱导的小鼠睡眠时间，还能显著增加家兔的深睡眠。RESULTS Piperine could reduce the spontaneous activity of mice and prolong the sleep time induced by sodium pentobarbital. It could also prolong the deep sleep of rabbits.
胡椒碱有很强的抗小鼠MES和对抗戊四唑引起的小鼠阵挛性发作的作用，并可明显增加小鼠脑内单胺类神经递质5-HT的含量。It could also prolong the deep sleep of rabbits. piperine afforded potent protection against MES and Met in mice. and was found to be able to increase the concentration of 5-HT.
研究人员在英国皮肤病杂志上发表的一篇文章中称，胡椒碱的这种作用在联合紫外线照射的光照疗法时效果尤好。Piperine was particularly effective when combined with phototherapy treatment using ultraviolet radiation, the researchers said in a study to be published in the British Journal of Dermatology.