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所有实验小鼠自3周龄断奶后高脂饲喂。All mice were fed an "atherogenic diet" from the age of 3 weeks after being weaned.
氧化修饰则从各个方面削弱高密度脂蛋白的抗动脉硬化效应。Whereas the oxidative modification of HDL may impair its anti atherogenic function.
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当这两种因素都存在时,动脉损伤可能会扩大和蔓延。The lesions appear to be larger and more diffuse when both these atherogenic factors are present.
然而,在机体的血管再生和动脉硬化的形成进程中,这些内皮祖细胞的作用和机制还不太明确。It is not clear yet, however, whether these EPCs are essential for these angiogenic and atherogenic processes.
促进氧化低密度脂蛋白的形成,促进脂质沉积于动脉壁等。It may lead to increase susceptibility of low density lipoprotein to oxidation that makes them more atherogenic.
贝特类可有效治疗致动脉粥样硬化性脂代谢异常,尤其可降低血清甘油三酯。Fibrates are effective for modifying atherogenic dyslipidaemia, and particularly for lowering serum triglycerides.
在实验老鼠中,膳食大蒜和洋葱可以减少由于膳食引起的动脉粥样化胆结石的发生率。Dietary garlic and onion reduce the incidence of atherogenic diet-induced cholesterol gallstones in experimental mice
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家族性复合高脂血症患者脂合素水平下降促致动脉粥样硬化脂质形成。Decreased adiponectin levels in familial combined hyperlipidemia patients contribute to the atherogenic lipid profile.
最近发现的因素,调节动脉粥样硬化的脂蛋白的水平,动脉炎的关键发起人,将提交。Recently discovered factors that regulate levels of atherogenic lipoproteins, key initiators of arterial inflammation, will be presented.
婴儿配方奶喂养和父母吸烟可能是婴儿在最初的几个月中引起动脉壁损伤的原因。Baby formula feeding and parental cigarette smoking might have an atherogenic effect on the coronary walls as from the first months of life.
血管壁中巨噬细胞产生脂蛋白脂酶,使脂质积聚于动脉壁内,促进动脉粥样硬化进展。Macrophages constitutively synthesize LPL, which may contribute to lipid accumulation within the arterial wall, promoting the atherogenic process.
研究鱼油和普罗布考对致动脉粥样硬化饮食饲养2周的大鼠体内单核细胞与主动脉内皮黏附的影响。We have examined the influence of both dietary fish oil and probucol on monocyte adhesion to the aortic endothelium rats fed an atherogenic diet for 2 weeks.
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目的探讨体检人群高尿酸血症与血致动脉硬化指数、非高密度脂蛋白胆固醇水平相关性及意义。Objective To analyze the correlation between hyperuricemia and non-high density lipoprotein cholesterol and atherogenic index of plasma in a normal population.
最近几年,大量的基础和临床研究都证实低的或者很高的内皮剪切力加速改变一个致动脉粥样硬化内皮基因型。In recent years a number of basic and clinical studies have provided evidence that low or turbulent wall shear stress promotes an atherogenic endothelial gene profile.
“因此,”研究者说,“非诺贝特和联合治疗更能将B型LDL转变为更具有浮力,致动脉粥样硬化作用较低的LDL”"Thus, " the investigators say, "fenofibrate and combination therapy favored the shift from LDL cholesterol pattern B to the more buoyant, less atherogenic LDL cholesterol. "
目的克隆、分离血管内皮细胞在致动脉粥样硬化因素作用下差异表达的基因,了解动脉粥样硬化发生的分子机制。Objective To isolate and clone the differential expressed genes induced by atherogenic factors on vascular endothelium and to understand the molecular mechanism of atherosclerosis.