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核小体是染色质的基本单位。Nucleosome is the basic unit of chromatin.
一种组蛋白的八聚物把DNA打包成一种叫做核小体的结构。An octa-mer of histones package DNA into a structure called a nucleosome.
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在核小体中,每个组蛋白二聚体分别由哪几种组蛋白组成?Which combinations of histones form"histone-fold"dimers with each other in the nucleosome?
DNA和组蛋白的复合物。参见核小体。Chromatin --- The complex of DNA and proteins of which chromosomes are composed. See also nucleosome.
在真核细胞中,DNA被包装成染色质,其重复单元为核小体。In eukaryotic cells, DNA is packaged into chromatin. The repeating unit of chromatin is called nucleosome.
人们很早就注意到,真核细胞中核小体核心组蛋白N-端尾部的乙酰化水平与基因活化密切相关。It has been known for some time that the acetylation of N-termini of core histones in nucleosome is associated with gene activation.
核小体结构上的改变影响了DNA的可接近性,并能够形成基因组中染色质的专门区域。Alterations in nucleosome structure affect the accessibility of the DNA and can generate specialized domains of chromatin in the genome.
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蛋白-DNA核小体复合体,依次包装成重复单位叫做染色质,染色质是染色体的构建模块。The protein-DNA nucleosome complexes, in turn, are packed into repeating units called chromatin, which is the building block of chromosomes.
在适当的参数条件下,得到了合理的结果,即DNA能够缠绕组蛋白约两圈形成准核小体结构。We numerically simulate the interaction between DNA and a histone. And we get the nucleosome structure. DNA wraps around histone about 2 loops.
因此核小体是细胞内遗传过程的一个关键靶标,也是解密正常与异常细胞工作方式的科学探索活动的一个焦点。The nucleosome is therefore a key target of genetic processes in a cell and a focus of scientific investigations into how normal and diseased cells work.
核心过程的表观遗传的产业包括DNA甲基化、组蛋白改性、核小体重建、核染色质动力学和互动子都存在。Core processes of epigenetic inheritance include DNA methylation, histone modification, nucleosome remodeling, nuclear dynamics and chromatin interaction with non-coding RNAs.