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克隆不应答和抑制细胞是耐受的主要机制。Clonal anergy and suppressor cells are main mechanisms of the tolerance.
目的探讨超抗原诱导T细胞无能的分子机制。Aim To explore the molecular mechanism of T cell anergy induced by superantigen SEA.
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介绍了蒸发式冷凝器的特点、工作原理、结构型式及其节能效果。This article introduces its characteristic, working principle, structure type and saving anergy effect.
结论CTLA-4表面表达水平的升高很可能与T细胞无能状态的诱导有关。The enhanced cell surface expression of CTLA-4 is likely responsible for the induction of T cell anergy.
阻断该通路可以导致抗原特异性的免疫耐受和克隆不应答状态。Inhibition of this pathway results in development of antigen-specific unresponsiveness and clonal anergy.
不同分化状态、不同亚型的树突状细胞诱导不同方向的免疫应答。Differentiation and subtype of DC is associated with initiating immune response or inducing immune anergy.
以往观点认为,T细胞免疫耐受机制主要有克隆无能和克隆删除两种学说。The clone anergy and clone deletion are considered as the major theories of the immunotolerance mechanism.
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然而,有些T细胞处于未激发状态,事实上他们被称为无反应性,耐受性的过程灭活了。Howeer, some T cells are not actiated, in fact they are inactiated by a process called anergy or tolerance.
通过对其能量利用过程的分析,引入可用和折合的概念。Introduces the concepts of available anergy and reduced exergy by analysing the energy utilization process.
然而,有些T细胞处于未激发状态,事实上他们被称为无反应性,耐受性的过程灭活了。Howeer, some T cells are not actiated, in fact they are inactivated by a process called anergy or tolerance.
然而,有些T细胞处于未激发状态,事实上他们被称为无反应性,耐受性的过程灭活了。However, some T cells are not activated, in fact they are inactivated by a process called anergy or tolerance.
你有足够的力量,足够的精力和足够的时间来这里上网,你自己怎么不开一家公司去赚“大钱”?You have great power, great anergy and enough time to surf the internet, why you can't start a company to earn "great money"?
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在TCR识别外来抗原的同时给予可溶性CTLA-4,在体外可诱导T细胞无应答,在体内则可诱导特异性免疫耐受。While the TCR engagement with specific antigen, the administration of CTLA-4Ig can induce T cell anergy in vitro or tolerance in vivo.
结论嵌合状态与肾移植耐受存在明显相关性,克隆不应答、抑制细胞参与了耐受的形成。Several other mechanisms may by theorized for the induction of tolerance in this renal transplant model, including clonal anergy and suppressive cells.
低剂量口服抗原主要通过调节性T细胞分泌抑制性细胞因子介导免疫抑制,高剂量口服抗原主要引起T细胞清除或T细胞失能。The feeding of low antigen doses leads to induction of regulatory cell secretion of immunosuppressive cytokines, whereas higher doses favor clonal deletion and anergy.
介绍了蒸发式冷凝器的特点、工作原理、结构型式及其节能效果。After 2 years operation, it shows marked saving effect of water and power. This article introduces its characteristic, working principle, structure type and saving anergy effect.
近来认为,MSCs通过诱导分裂停滞无反应性来对多克隆和特异抗原T细胞反应有明显的免疫抑制作用。Recently, MSC have been shown to exert a profound immunosuppressive effect on polyclonal as well as antigen-specific T cell responses by inducing a state of division arrest anergy.
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分析了能量、火用和火无之间的内在联系,指出了视火用和火无为能量中的两个部分的传统认识的局限性。We have analyzed the relationships of conversion among energy, exergy and anergy in a thermodynamics system. The results show that it is incorrect to consider exergy and anergy as two parts of energy.