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JAK2单倍体是发生骨髓增生性肿瘤的一个重要的危险因子。JAK2 haplotype is a major risk factor for the development of myeloproliferative neoplasms.

目的探讨骨髓增生性疾病致门静脉高压症的诊断及治疗。Objective To discuss the diagnosis and treatment of portal hypertension secondary to myeloproliferative diseases.

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慢性粒细胞白血病是一种造血干细胞克隆性增殖所致的骨髓增殖性疾病。Chronic myelocytic leukemia is a clonal proliferation of hematopoietic stem cells caused by myeloproliferative disorders.

疾病可引发脊髓发育不良、脊髓增殖失调，急性髓性白血病和支气管瘤。Conditions included myelodysplastic syndrome, myeloproliferative disorders, acute myeloid leukemia, and bronchial carcinoma.

在BCR-ABL阴性的骨髓增殖性疾病的发病机制中，JAK2V617F点突变的发现是一个重大的突破。In BCR-ABL fusion gene negative myeloproliferative diseases, the discovery of JAK2V617F point mutation is an important landmark.

结论髓系肉瘤可孤立出现或发生于各种骨髓增生性疾病的病程中或经治疗缓解后。Conclusions Myeloid sarcoma may precede, develop in a background of myeloproliferative disorder or even after remission of the disease.

这样的脾肿大通常预示有骨髓增生型疾病，例如慢性髓性白血病或骨髓纤维化。Such massive splenomegaly is usually indicative of some myeloproliferative disease such as chronic myelogenous leukemia or myelofibrosis.

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JAK2基因V617F突变在骨髓增殖性疾病中有较高的检出率，可作为骨髓增殖性疾病特异性诊断指标。There is high frequency of JAK2 V617F mutation in myeloproliferative disorders and it could be used as the diagnostic marker for myeloproliferative disorders.

提示在所检病例中存在HHV?6感染，其中与急性白血病、淋巴瘤及骨髓增生异常综合症关系尤为密切。The results show that the examined patients are infected by HHV 6, which has a good relationship with leukemia, lymphoma, myeloproliferative disorder syndrome, and multiple myeloma.

它曾被报告与淋巴母细胞转变相关的急性骨髓性白血病、骨髓增生性疾病、脊髓发育不全症等等，甚至于那些不具已知的血液学异常相关的病人们身上。It has been reported in association with acute myeloid leukemia, myeloproliferative disorders, and myelodysplasia in blast transformation, as well as in patients with no known hematological disorders.