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防止咖啡中的赭曲霉毒素A污染Prevention of Ochratoxin A contamination in coffee

谷类作物和谷类作物产品中赭曲霉素A的测定。Determination of ochratoxin A in cereals and cereal products.

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赭曲霉素A是一种毒枝菌素，据知对肾脏有毒性作用。Ochratoxin A is a mycotoxin known to be toxic to the kidneys.

事务委员会与政府当局讨论有关食物中赭曲霉毒素A含量的研究结果。The Panel discussed with the Administration the findings of study on ochratoxin A in food.

另外一份准备通过的规范草案将防止或减少葡萄酒中赭曲霉素A污染。Another draft code up for adoption would prevent or reduce Ochratoxin A contamination in wine.

赭曲毒素B是赭曲毒素A的非氯化类似物，后者受到广泛的研究。Ochratoxin B is the non-chlorinated analogue of the much more extensively studied ochratoxin A.

本文建立了一般实验室条件下棕曲霉毒素A大的制备方法。A method has boon discussed for the preparation of ochratoxin A under general laboratory condition.

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经过以上条件净化处理，得到相对干净的色谱图，可以满足对葡萄酒中赭曲霉毒素A的定量检测。Under the above conditions, clean chromatograms were obtained for quantitative detection of Ochratoxin A in grape wine.

此外，本压电免疫感测器具良好的专一性，在高浓度的赭麴毒素的存在下并不会产生显著的交叉反应。It was observed that the citrinin assay is specific, no significant cross reactivity was observed in the presence of ochratoxin A.

赭曲毒素B几乎没有得到研究关注，它的作用方式和潜在的危害是通过赭曲毒素A推断的。Ochratoxin B has received little focused investigation and its mode of action and potential hazards have been inferred from ochratoxin A.

毒理学研究表明，赭曲霉毒素A具有很强的肝脏毒性和肾脏毒性，并有致畸、致突变和致癌作用。Toxicological studies indicated that ochratoxin A is a teratogenic, mutagenic and carcinogenic mycotoxin with the strong toxic effects on liver and kidney.

赭曲毒素A是氯化苯并吡喃，和苯丙氨酸的氨基酸连接，由一些曲霉菌属和青霉菌属产生，和食物腐败变质密切相关。Ochratoxin A is a chlorinated benzopyran coupled to the amino acid phenylalanine, produced by several Aspergillus and Penicillium sp. associated with food spoilage.

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赭曲霉毒素A广泛存在于谷物及谷物产品、香料和咖啡豆等产品中，严重危害人类健康。OTA occurs predominantly in cereal grains, cereal products, spices, coffee beans and legumes. Ochratoxin A seriously threats human and animal healthy and life safety.

结论该方法的测定结果满意，是目前国内外测定粮食、饲料中赭曲霉素的科学而理想的方法。Conclusion The detection result of the method is satisfactory, which is a scientific and perfect method for detection of Ochratoxin contained in grain and fodder at home and abroad.

赭曲毒素A通过诱导DNA链的断裂、姐妹染色单体的互换、DNA加合物的形成或者活性氧发挥作用，但是作为一种毒素其作用机制仍然没有被解决。Ochratoxin A may act by induction of DNA strand breaks, sister chromatid exchanges, DNA adduct formation, or reactive oxygen but the mechanism of action as a toxin is not yet resolved.