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作者研究了血浆和组织激肽释放酶激活纤溶酶原的机制。We studied the mechanism of plasma and tissue kallikrein in activating plasminogen.

该药能够克服现用药物出血的缺点。因为BB-10153是由凝血酶激活的。BB-10153 is an engineered variant of human plasminogen that is activated to plasmin by thrombin.

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瑞替普酶是人类组织型纤溶酶原激活物的一部份，在大肠杆菌中合成。Reteplase is a part of human tissue-type plasminogen . It is expressed in Escherichia Coli cells.

尿激酶是一种纤溶酶原激活剂，临床上用于治疗血栓。Urokinase, a human plasminogen activator, is used clinically to promote the dissolution of thrombi.

HMGB1与纤维蛋白酶原、基质金属蛋白酶的活化、细胞骨架重组等有关。HMGB1 plays roles in activation of plasminogen and matrix metalloproteases, reorganization of cytoskeleton.

为规模化快速纯化临床用高纯度纤溶酶原提供了新方法。This method provided a new, fast and efficient method for large-scale purification of plasminogen for clinic use.

在两个试验中，在组织纤维蛋白溶酶原激活剂使用前，都先用NIHSS评分。NIHSS scores were determined before tissue plasminogen activator bolus and at 60 and 120 minutes in both data sets.

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目的观察应用重组组织型纤溶酶原激活剂溶栓治疗急性心肌梗死的效果。Objective To observe the effect of recombinant tissue plasminogen activator in the treatment of acute myocardial infarction.

目的研究不同行为类型冠心病患者之间纤溶激活系统的变化。ObjectivesTo study the change of plasminogen activation system in different behavior type patients with coronary heart disease.

纤维蛋白酶及其酶原是存在于乳中的一对主要碱性蛋白酶，通过水解乳蛋白对乳及乳制品的品质产生影响。Plasmin and plasminogen is a major pair of alkaline proteinase in milk, which affects dairy products by hydrolyzing milk proteins.

高酚早餐组另一血栓促进因子——纤维蛋白溶酶原活化抑制因子-1的活性也呈现显著降低。The high-phenol group also experienced a greater drop in the activity of another clot promoter, plasminogen activator inhibitor-1.

目的探讨急性冠状动脉综合征患者内皮组织纤溶酶原激活剂储备功能的变化规律。Objective To study the changes of the endothelial tissue plasminogen activator reserve capacity in patients with acute coronary syndromes.

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脑血管病变时，中枢神经系统中的血源性丝氨酸蛋白酶，如凝血酶、组织纤维蛋白溶酶原激活剂和纤溶酶等的出现很有意义。The appearance of serine proteases such as thrombin, tissue plasminogen activator and plasmin in the CNS have come under increasing scrutiny.

在卒中的介入急救中，静脉注射重组组织纤溶酶原激活剂依然被认定为最有效的。Intravenous administration of recombinant tissue plasminogen activator remains the most beneficial proven intervention for emergency treatment of stroke.

测序结果表明这两种方法能快速，准确地筛选出阳性克隆。The screening of human tissue plasminogen activator recombinant plasmid showed that the two methods can recognize the positive colones quickly and correctly.

最近发现SPC促进细胞的移动，诱导成纤维细胞表达与细胞移动有关的血纤维蛋白溶酶原激活剂。Recently, a lot of studies have been demonstrated that SPC increased cell migration and induced the expression of plasminogen activator related to cell migration.

这一现象伴随血脑屏障的严重破坏和组织型纤维蛋白溶酶原激活剂治疗后的脑出血率增加。This was accompanied by severe disruption of the blood–brain barrier and an increased rate of intracerebral hemorrhages after tissue plasminogen activator treatment.

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该酶具有强烈的纤溶活力和水解BAEE的活力，能直接作用纤维蛋白和间接激活纤溶酶原。The enzyme showed strong fibrinolytic activity on fibrin and esterase activity in BAEE. It shows two effects, both acting on fibrin directly and activating plasminogen.

脑梗塞血浆PAI-1活性增高与IS及C肽呈正相关，PAI-1活性增高导致血浆纤溶活性降低，可能是IR引起脑梗塞的中间环节。The PAI-1 obvious correlates with the IS and CP. The increasement of PAI-1 causing reduction of serum plasminogen activator might be a intermediate process of IR and CBI.

纯化的t-PA与尿激酶相比较，发现前者有更高亲和纤维蛋白的能力。The purified t-PA has a higher affinity for fibrin than urokinase. In addition, the melanoma plasminogen activator appeared to be immunologically different from urokinase.