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同样的协同作用也见于KINK-1和喜树碱的联合治疗。Similarly synergistic effects were seen with KINK-1 and camptothecin.

第二部分是关于喜树碱结构修饰的研究。The second part of the treatise is study on modification of camptothecin.

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因而喜树碱衍生物成为研究的热点。Therefore, derivatives of camptothecin are becoming the focus of research.

喜树碱及其衍生物是一类具有抗癌活性的生物碱。Camptothecin and its derivatives are alkaloids possessing anti tumor activities.

喜树碱在体内存在内酯环形式和羧酸盐形式的平衡。In vivo camptothecin remains a balance of E-lactone form and Carboxylic salt form.

各处理对喜树幼苗内10-羟基喜树碱含量的影响无规律可循。No available rules can explain changes of 10-OH camptothecin content under all treatments.

目的对喜树碱类药物的一些特殊传递系统进行综述。Objective To review some delivery systems for camptothecin and its analogs in recent years.

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本方法是测喜树碱含量的新方法，具有快速、准确的特点。This method is a new one for determining camptothecin content and features rapidity and accuracy.

测定不同生长期喜树苗各器官中喜树碱的含量。The concentration of camptothecin was determined in different tissues of Camptotheca acuminata seedling.

该文总结了近年来喜树碱及其衍生物的合成与活性研究方面的最新进展。This paper summarized the synthesis and antitumor activity of camptothecin and its derivatives in recent years.

喜树碱与呋喃甲酸、吡啶甲酸、烟酸和异烟酸通过酯键进行偶联。Camptothecin was coupled with 2-furonic acid, pyridinecarboxylic acid, niacin and isonicotinic acid through ester bond.

结论随着新的药物传递系统的不断成熟与发展，喜树碱类药物将是十分有潜力的一类抗肿瘤药物。Conclusion As the development and maturation of some novel drug delivery system, camptothecin will be a kind of potential anticancer drugs.

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不同丛枝菌根真菌侵染喜树幼苗对喜树不同器官代谢的影响不同，主要表现为对幼苗根部喜树碱代谢的影响。It is different that the effect on camptothecin metabolism in arbuscular mycorrhizal C. acuminata seedlings and it mainly reflected in roots.

结果通过一些特殊的传递方法与策略，可以解决喜树碱类药物所存在的溶解度、稳定性、毒性和不良反应等问题。Result The problems of camptothecin such as solubility, stability and side effects could be solved by special delivery methods and strategies.

由此表明，丛枝菌根对喜树幼苗根部喜树碱积累的促进作用主要表现为三、四级根喜树碱含量的增加。It showed that arbuscular mycorrhiza did not improve the accumulation of camptothecin in all roots, but mainly improved in tertiary roots and fourth roots.

结果表明紫杉醇、三尖杉酯碱、高三尖杉酯碱及喜树碱对B16BL6和HT1080细胞增殖均有很强的抑制作用。Results demonstrated that taxol, harringtonine, homoharringtonine and camptothecin exhibited significant inhibition of cell growth of B16BL6 and HT1080 cells.

通过对喜树碱类药物研发过程的历史回顾，探讨其存在的哲学意义和对其它植物药研发的价值。Through reviewing the process of developing camptothecin and its derivatives, to discuss its philosophy meanings and the value to development of other plant drugs.

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体外抗肿瘤活性试验说明，两个前药表现出中等强度的细胞毒性，略小于中间体20-氧琥珀酸喜树碱，远远小于母体化合物-喜树碱。In vitro cytotoxicity test, the two prodrugs were slightly less cytotoxic than the intermediate, while greatly less cytotoxic than the parent compound camptothecin.

外源ABA的使用可以缓解因为渗透胁迫引起的渗透调节物质含量和抗氧化酶类活性变化，但是对喜树碱含量并没有显著影响。Exogenous ABA proved to pose negative effects on osmotic materials accumulation and antioxidant enzymes'activity, however, with no marked effects on camptothecin content.