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醛糖还原酶是多元醇通路的限速酶，此酶的激活被认为与糖尿病慢性并发症有关。Aldose reductase is a key regulatory enzyme in the substrate flux via polyol pathway.

结论两种化合物有望作为黄酮类醛糖还原酶抑制剂结构改造前体。Conclusion The two compounds can be used as lead compounds for Aldose Reductase inhibitors.

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目的红细胞醛糖还原酶测定荧光法的实验探讨。Objective To investigate the setup of fluorometric determination of erythrocyte aldose reductase.

醛式糖还原酶是通常是存在在眼睛和在许多其它身体部位的酵素。Aldose reductase is an enzyme that is normally present in the eye and in many other parts of the body.

通过大量实验，研究了溴水氧化醛糖和酮糖的条件、产物和机理。The conditional, product and mechanism of Bormine Water oxidating Aldose and Ketose are discussed in this paper.

本文主要概述了微生物来源的醛糖还原酶抑制剂的研究进展。This review mainly gives a brief account of the progress of research on aldose reductase inhibitors from microorganisms.

预计以醛糖还原酶为靶点的新药研究和开发将取得重要进展。It is prospective that new drug development with aldose reductase as a potential target can achieve significant progress.

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结果与对照组相比，干预组醛糖还原酶基因表达下调。Results compared with the control group, the aldose reductase gene was down-regulated in the captopril intervention group.

依帕司他是目前唯一上市的醛糖还原酶特异性抑制剂，通过阻断多元醇通路而发挥作用。Epalrestat is the only available and specific inhibitor of aldose reductase. It can exert its action by blocking polyol pathway.

以依帕司他为阳性对照药，采用大鼠晶状体醛糖还原酶对目标化合物醛糖还原酶抑制活性进行初步评价。Using epalrestat as a control, the aldose reductase inhibitory activities of the compounds obtained were evaluated on rat lens aldose reductase in vitro.

发现了其中一个衍生物对醛糖还原酶的抑制强于先导化合物一个数量级，但无抗氧化作用。The pharmacological activities of these derivatives in aldose reductase inhibition, alpha-glucsidase inhibition and anti-oxidation have been investigated.

用香草醛-浓硫酸试剂显色比色分析了龙芽木根和叶中三萜皂甙的含量。Measuring the content of triterpenoid saponin in agrimony Aralia elata by the color development reaction & colorimetry between herb aldose and oil of vitriol reagent.

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醛糖还原酶是多元醇代谢通路中的限速酶，醛糖还原酶抑制剂能有效抑制此通路，减慢或改善糖尿病并发症。Aldose reductase is a key rate?limiting enzyme in the pathway, while aldose reductase inhibitors can inhibit the pathway and alleviate the symptoms of diabetic complications.

麦芽糖是一个还原糖因为它的醛基是游离的可与氧化剂反应，事实上如果它是一个游离醛糖，可以发生几乎任何反应。Maltose is a reducing sugar because its aldehyde group is free to react with oxidants and, in fact, to undergo almost all reactions as though it were present as a free aldose.

此外小组确定，给注入人结肠腺癌细胞的小鼠以醛糖还原酶小片段干扰RNA能够完全阻止肿瘤的发展。In addition, the team established that administration of aldose reductase small interfering RNA to mice bearing human colon adenocarcinoma cells completely arrested tumor progression.

小鼠胰岛培养72小时后，酶抑制剂处理过的胰岛山梨醇水平较对照组显著降低。After culture for 72 hours, the levels of the sorbitol from the islets treated with the aldose reductase inhibitor were significantly decreased in comparison with those from the control islets.