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最后将该嵌合体小鼠的骨髓移植到宿主体内。The bone marrow of the chimerism mice was grafted into the host mice.
通过PCR-SSP方法在外周血中检测到供体淋巴细胞嵌合体有助于GVHD的诊断。The diagnosis of GVHD is supported by PCR-SSP to detect peripheral blood lymphocyte chimerism.
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全部供者粒细胞嵌合体形成中位时间为4周，全部供者T细胞形成中位时间为8周。The median time to full donor myeloid cell and T cell chimerism was 4 and 8 weeks respectively.
嵌和性的水平无论在外周血还是在肝内，患者和对照均无明显差异。The level of chimerism did not differ between patients and controls either in blood or in liver.
混合嵌合体中供者DNA比例的下降预示着早期排斥或复发。The decrease of donor DNA amounts in mixed chimerism foreshowed the early graft rejection or relapse.
通过自然途径获得的微嵌合状态有可能用于治疗，而我们的研究发现正好提高了这一可能性。This study aims to investigate whether splenocytes can be used to maintain chimerism and to prolong graft survival.
移植后基因嵌合程度试验是侦测捐赠者干细胞植入及评估复发的重要方法。Post-transplantation chimerism testing is important to monitor the engraftment of donor stem cells and the diagnosis of relapse.
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造血干细胞混合嵌合体是指两个不同基因型个体的骨髓造血干细胞共存的一种状态。Mixed hematopoietic chimerism is a state in which bone marrow hematopoietic stem cells from two genetically different individuals coexist.
造血嵌合能够对肾移植产生持久有力的免疫耐受，但对于皮肤移植无效。Hematopoietic chimerism produces durable and robust immune tolerance to kidney allografts, although incomplete tolerance to donor skin grafting.
对异基因外周血造血干细胞移植的猕猴，用Y特异性序列分析法和性别染色体检测法于移植后7及14天均检测到雄性供者嵌合。Male donor chimerism were found on day 7 and 14 after allogeneic stem cell transplantation by Y-specific sequence and chromosome karyotype analysis.
结论NAST早期造血细胞嵌合体检测及确定ME对判断植入、预测移植排斥具有重要意义。Conclusion It suggested that molecular monitoring of the early dynamics of chimerism after NAST could be useful in predicting engraftment, or rejection.
陈江华。王仁定。吴建永供体骨髓输注肾移植动态变化及对排斥的受者外周血嵌合体影响。Garcia-Morales R. Carreno M. Mathew J The effects of chimerism cells following donor bone marrow infusions as detected by PCR-flow assays in kidney transplant recipients.
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介绍一些具体方案，包括建立异基因骨髓嵌合体、阻断T细胞活化第二信号和转基因技术诱导移植免疫耐受。Some experimental protocols were introduced including mixed chimerism of allogeneic bone marrow, blockade of co-stimulation signal and transgene technology for transplantation tolerance induction.