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目的建立纯度较高的适于实验研究的人蜕膜细胞。Objective To establish highly purified functional human decidual cells from human placental in vitro.

孕酮可调节蜕膜细胞活性肾素的合成与分泌。The synthesis and secretion of active renin were regulated by progesterone in incubated decidual cells.

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目的探讨不明原因早期自然流产患者蜕膜巨噬细胞功能的变化。Objective To analyse changes of decidual macrophage function from patients with unexplained spontaneous early abortion.

目的探讨不明原因早期自然流产患者蜕膜淋巴细胞功能的变化。Objective To analyse changes of decidual lymphocytic function from patients with unexplained spontaneous early abortion.

目的建立分散的人蜕膜质细胞培养模型以用于抗生育药物的筛选研究。Objective To establish an in vitro model of human decidual cell culture for screening drugs and studying antifertility drugs.

结论人蜕膜细胞培养作为抗生育药物初筛模型有较多优点，有待进一步发展推广。Conclusion Human decidual cell culture has more advantages as a model for screening antifertility drugs but it deserves further research to develop.

有时没有正常的蜕膜形成，胎盘绒毛直接侵入子宫肌层，如图示，称为胎盘粘连。Sometimes no normal decidual plate forms in pregnancy, and placental villi invade directly into myometrium, as seen here. This condition in known as placenta accreta.

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上述结果提示E4BP4基因可能通过促进着床位点基质细胞的增殖和抑制蜕膜细胞的凋亡而参与胚胎着床过程的调控。These results indicated that E4BP4 may play a critical role in embryo implantation process by promoting stromal cell proliferation and inhibiting decidual cell apoptosis.

于吸刮术时收集月经周期增殖期和分泌期的子宫内膜组织及妊娠6～11周的新鲜壁蜕膜组织。Fresh human endometrium in the follicular and luteal phases of the menstrual cycle and wall decidual tissues at 6-11 weeks of gestation were collected by suction curettage.

人早孕子宫蜕膜组织中存在高水平的活性肾素，性类固醇激素可调节蜕膜细胞活性肾素的表达，子宫局部肾素-血管紧张素系统在妊娠过程中发挥了重要作用。These data indicate that a high level of active renin in decidual tissue at early pregnancy plays an important role in the uterine renin-angiotensin system during pregnancy.

实验拟建立良好的小鼠子宫蜕膜基质细胞培养方法，为进一步建立蜕膜细胞共培养系统将为研究病理性妊娠打下良好的基础。This study aimed to establish a culture method for DSC in mouse uterus. The construction of a co-cultured system of decidual cells will lay a good foundation to study pathological pregnancy.

结论患者蜕膜巨噬细胞功能显著增高，可能参与了免疫学发病机制，为疾病预测及制订相应的防治措施提供了一定的实验依据。Conclusion The function of patient decidual macrophage upregulates highly, these datas and the experimental evidences about the research of immunol pathogenesis, predict and prevent in this disease.