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我们有其他非侵入性方法来诊断并检测肝纤维化。We have other non-invasive methods to diagnose and monitor liver fibrogenesis.
目的研究肝纤维化的发生机制,寻找新的与肝纤维化相关的生物学标志物。Objective To study the mechanism of liver fibrogenesis and to find new non-invasive biomarkers.
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我们知道肝星状细胞还是纤维化过程中细胞外基质的主要来源。We know that hepatic stellate cells are still the major source of extracellular matrix during fibrogenesis.
目的研究骨髓干细胞在肝纤维化形成环境中向肝细胞定向分化。Objective To observe the differentiation of bone marrow stem cells in rat hepatic fibrogenesis environment into hepatocytes.
慢性丙型肝炎可能通过肝脏星形胶质细胞的活化、或者间接通过促进氧化应激和受感染细胞的凋亡,直接诱导纤维形成。HC may induce fibrogenesis directly by hepatic stellate cell activation or indirectly by promoting oxidative stress and apoptosis of infected cells.
随着我们在信号转导通路方面知识的积累,我们会有更多的机会阻断这种通路,从而阻断肝纤维化进程。As we learn more about the signal transduction pathway, we will have more chances to try to block this pathway thereby inhibiting liver fibrogenesis.
丙型肝炎病毒可能诱发肝纤维化肝星状细胞的活化或间接通过促进氧化应激和感染的细胞凋亡。HCV may induce fibrogenesis directly by hepatic stellate cell activation or indirectly by promoting oxidative stress and apoptosis of infected cells.
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肝硬化是一种常见的慢性肝病,是由一种或多种病因长期或反复作用,引起肝脏弥漫性损害。Liver cirrhosis is the common chronic disease that results in suffusive impairment of liver, which is caused by one or several fibrogenesis pathogens.
肝纤维化作为一种普遍多发的疾病,如不能及时诊断和治疗可发展为肝硬化。The hepatic fibrogenesis is a kind of disease happens generally, which may develop to hepatic cirrhosis if it couldn't been diagnosed and treated promptly.
内源性大麻素系统在血吸虫性肝纤维化的发生发展中发挥一定作用。So we concluded that the endogenous cannabinoids may participate in liver fibrogenesis and portal hypertension in mouse liver fibrosis infected with S. japonicum.
目的从转录水平研究兔日本血吸虫病肝纤维化形成过程中胶原的合成与降解的规律。Objective To study the role of the synthesis and degradation of collagen at the transcription level during liver fibrogenesis due to schistosomiasis japonica in rabbits.
结论从转录水平证实胶原合成大于降解时可导致肝纤维化形成。Conclusions It was confirmed at transcription level that when the quantity of collagen synthesis was higher than that of collagen degradation liver fibrogenesis may be resulted in.
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凋亡,间接地通过减少肝损伤和炎症来抑制肝纤维化的形成。"This study suggests that blocking RSK activity inhibits fibrogenesis directly by inducing HSC apoptosis, and indirectly, by reducing liver injury and inflammation, " the authors conclude.
在纤维形成过程中,促纤维形成细胞、细胞因子、生长因子、酶及其抑制因子发挥了十分重要的作用。Fibrogenic cells, cytokines, growth factors, enzymes, and their inhibitors play a pivotal role in fibrogenesis. These will advance our recognition for pathogenic mechanisms of hepatic fibrosis.