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我们的第2条染色体在中心部位含有端粒DNA。Our second chromosome has telomere DNA at the center.

四联体是端粒形成的一种特殊的结构。G- quadruplex is a special structure formed by telomere.

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它的中心部位将有端粒DNA，而且会同时含有两个着丝粒。It would have telomere DNA at the center, and it would have two centromeres.

端粒酶，是一种催化延长端粒末端的反向转录酶。Telomerase is a kind of ERT which causes catalysis and prolong the end of telomere.

卡罗尔·葛莱德尔和布莱克本还分离出端粒酶，即合成端粒DNA所需要的一种酶。Carol Greider and Blackburn identified telomerase, the enzyme that makes telomere DNA.

此后研究发现许多的植物和动物，从阿米巴到人类都具有端粒DNA。Later it became clear that most plants and animals, from amoeba to man have telomere DNA.

结论端粒缩短并激活端粒酶是涎腺肿瘤形成的重要因素。Conclusion Telomere reduction and telomerase activation are critical factor during oncogenesis.

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端粒功能是细胞和整体辐射敏感性的决定因素之一。Telomere function is one of the factors that determine radiosensitivity of cells and whole organism.

但是，如果端粒酶非常活跃的话，端粒的长度得以维持，而细胞则能保持年轻。But if the telomerase enzyme is very active, telomere lengths are maintained and cells are kept young.

随着时间延长，端粒末端酶会减少，最终端粒也会缩短，细胞就不能继续分裂。Over time, this telomerase dwindles and eventually the telomere shortens and the cell becomes inactive.

端粒本身没有任何密码功能，它就像一顶高帽子置于染色体头上。Telomere does not have any password function, which is like a tall paper hat at the head of chromosomes.

在染色体的顶端覆盖着一段非常特殊的DNA，这片区域叫做“端粒”。The tips of all chromosomes are covered with a very special DNA sequence, in a region called the telomere.

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端粒的长度与寿命的长短有关，染色体端粒越短，它所在的生命跨度也就越短。Telomere length tends to shorten with age, and shorter telomeres tend to be linked with shorter life spans.

端粒长度的测量，可以给一个问题中的单元格的复制史的洞察。The measurement of telomere length can give an insight into the replicative history of the cells in question.

端粒长度，跟胆固醇水平一样是预测冠心病的很好的指标。Telomere length was as good as cholesterol levels at predicting the risk of developing cardiovascular disease.

综述了NBS1在DNA损伤反应中的作用，并探讨NBS1参与维持端粒稳定中的分子机制。The mechanisms of NBS1 in DNA damage response and maintenance of telomere stability are reviewed in this paper.

目的建立检测端粒酶活性的银染端粒重复扩增法。Objective To establish a silver-staining telomere repeat amplification protocol for detecting telomerase activity.

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曾有报道称重度再障中端粒长度存有差异，但其临床意义未知。Variations in telomere length have been reported in severe aplastic anemia but their clinical significance is unknown.

可以肯定的是，研究数据表明生理循环中更高水平的维生素D和较长的端粒有关。Sure enough, the data indicated that higher levels of circulating vitamin D was associated with longer telomere length.

目的观察不同浓度几种化疗药物对人肝癌BEL-7404细胞端粒长度的影响。Objective To investigate the effects of chemotherapeutic drugs with different dose on telomere length of BEL-7404 cells.