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结论单倍型TGC与大骨节病具有相关性。Conclusion The polymorphism of haplotype TGC is associated with KBD.

结论换粮预防大骨节病效果显著。Conclusions It's a useful method to prevent KBD by exchanging grain.

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据郭教授介绍，有的村子里几乎全村人都有大骨节病。In some villages, nearly everyone has Kashin-Beck, according to Dr. Guo.

方法按照国家大骨节病监测方案进行。Methods It was carried out in the line with the national monitoring scenario for KBD.

本文报告了大骨节病儿童尿液游离氨基酸谱短期动态变化的情况。This paper reported the change of amino acid profile in urine in KBDchildren in short—term.

目的研究大骨节病对跟腱力学性质的影响。Objective Did research on the biomechanics property's effect on the viscoelasticity of tendon.

目的掌握大骨节病病情动态，为大骨节病防治研究提供基础资料。Objective To understand KBD prevalence state, provide academic data for KBD prevention and treatment.

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方法对近5年来收治的25例大骨节病致踝管综合征患者的诊断和治疗进行分析。Methods 25 cases with tarsal tunnel syndrome caused by KBD in recent 5 years were involved in this study.

人体硒摄入量不足是该区大骨节病病情复发活跃的主要因素之一。Deficiency of adsorbing Se for human body is main reason for the active incidence of the KBD disease in the studying area.

目的考察当地自然状况，病情现状和生产生活方式等，制订大骨节病防制策略。Objective To investigate natural condition, prevalent status, production and living manners of the KBD area in Rangtang county.

我们的数据并没有显示低硒与大骨节病发病的易感位点有显著相互作用。Our data did not show a significant interaction between low selenium and the susceptibility loci in the occurrence of Kashin-Beck disease.

采用有效的补硒措施，提高和改善人体硒水平是预防大骨节病复发的关键。It is a key factor that a prevention from the KBD disease is to improve the content of adsorbing Se for children with KBD disease by efficient methods.

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方法用干预实验的流行病学方法，分别对补硒、补维生素C、主食粮食干燥治疗大骨节病的效果进行对比研究。Methods Using the epidemiologic methods of intervention, to compare the effect of Se supplement, Vit C supplement and cereals dryness on KBD's treatment.

和国内其他病区同样，大骨节病患儿及病区人群红细胞的硒含量及谷胱甘肽过氧化物酶活性，均在低水平。As in other endemic areas, the Seleniumcontent in erythrocyte and glutathione peroxidase activity in KBD Patientsare lower than that in non-endemic areas.

结果3省一致性出现的大骨节病致病危险因素有谷物受真菌毒素污染严重、低硒、卫生条件差。Results The severe cereal mycotoxin contamination, selenium-deficiency and poor sanitation condition were three prominent risk factors in the 3 provinces.

同时，病理形态学检查猴关节软骨和髓板软骨都出现大骨节病样的软骨细胞坏死。In addition, pathomorphological examination revealed chondrocytic necrosis in the articular cartilage and epiphyseal plate, resembling those observed in KBD.

研究的结果并不能确定究竟是哪个因素导致了大骨节病，但是政府仍然基于这些发现向研究项目拨款。The research couldn't definitely show that any of these factors was causing Kashin-Beck, but the government nonetheless allocated funds based on the findings.

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本研究结果可能有助于阐明某些变性型骨关节疾病的发病机理，例如因缺硒所致的大骨节病等。These results might be helpful in understanding the pathogenesis of some degenerative joint diseases, such as Kashin-Beck disease related to selenium deficiency.

就洪积土壤来说，其与大骨节病分布的关系似乎与土壤质地有一定的联系，底部砾石含量高的土壤多集中在大骨节病地区。For diluvial soils, KBD distribution was probably related with soil texture. Soils with high content of gravel in bottom layer are mostly concentrated on KBD affected area.

研究表明，在自然状态下，儿童大骨节病病情的变化是以人体硒营养变化为基础的骨质病变或修复的变化。It was found that the fluctuation of seriousness of children Kaschin-Beck disease had to do with the change of bone lesions or natural repair related to selenium nutrition.