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本发明提供了一种水溶性克罗米芬制剂。The present invention provides a water-soluble clomiphene preparation.

二甲双胍加克罗米芬治疗3个周期。Patients, in group C were treated by Metformin and Clomiphene for 3 cycles.

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本发明还提供了水溶性克罗米芬制剂的制备方法。Said invention also provides the preparation method of the said water-soluble clomiphene preparation.

在克罗米芬治疗组，血清雌激素和孕酮的水平明显升高。Levels of serum estradiol and progesterone were statistically significantly higher in the clomiphene citrate group.

方法腹部超声对103例不孕症患者的卵泡生长情况进行监测，采用克罗米芬及HCG治疗。Methods Abdomen ultrasound inspection ovum growth of 103 sterility cases patient, using Clomiphene and HCG for treatment.

克罗米芬，为人工合成的非甾体制剂，化学结构与烯雌酚相似。Clomiphene citrate for the synthetic system of non-steroidal agents, chemical structure and allyl phenol similar to estrogen.

结论腹腔镜单极电凝打孔术是多囊卵巢综合征耐克罗米酚不孕症的有效治疗方法。Conclusion Laparoscopic ovarian drilling is an effective treatment for clomiphene citrate-resistant infertile women with PCOS.

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结论克罗米酚在诱发排卵过程中可导致内源激素平衡紊乱。Conclusion Clomiphene therapy can lead to the disorder of estrogen and progesterone level during the course of ovulation induction.

提示克罗米芬及克罗米芬联合治疗对不育妇女及分娩的小儿是安全，有效的。This data indicate that clomiphene and combined clomiphene therapy is a safe, effective therapy for infertile women and their infants.

目的探讨在ODS柱上分离测定枸橼酸氯米芬的反相高效液相色谱法。Objective To develop a RP-HPLC method for the isolation and determination of clomiphene citrate on ODS Columns and its related substances.

结论中药周期疗法加氯米芬治疗，能提高排卵率，远期效果好，疗效巩固。Conclusion Chinese medicinal herbs plus clomiphene can increase ovulation rate, the long- term effect is good and the therapeutic effect is stable.

目的研究二甲双呱降低血清胰岛素诱发排卵来治疗多囊卵巢综合症。Objective To study metformin to reduce insulin secretion and increase ovulation and the ovulatory reponse to clomiphene in polycystic ovary syndrome.

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第一组为舒经酚和安慰剂治疗组，第二组接受二甲双胍和安慰剂组，第三组接受舒经酚和二甲双胍联用组。The first group receied clomiphene and a placebo, the second group receied metformin and a placebo, and the third group receied both metformin and clomiphene.

治疗措施减少雄激素的分泌，不育可以用氯菧酚胺促使排卵或用腹腔镜检查。Treatment attempts to reduce androgen production. Infertility may be treated with clomiphene citrate or gonadotropins to induce ovulation or with laparoscopy.

结论对氯米芬抵抗的PCOS患者予以二甲双胍预治疗，可改善IVM的治疗效果，提高临床妊娠率。Conclusion Pre-treatment with metformin may improve curative effect of IVM on the PCOS patients with clomiphene citrate resistance and the clinical pregnant rates.

结论来曲唑用于不孕妇女的促排卵治疗优于氯米芬，将来有可能替代氯米芬作为一线的诱发排卵药物。Conclusion Letrozole has more advantage than clomiphene citrate in ovulation treatment of infertile women. It is expected to replace clomiphene citrate as a first-line drug to induce ovulation.