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经鼻接种的流感病毒疫苗Intranasal influenza virus vaccine

鼻腔流感疫苗的功能显著。Intranasal flu vaccine appears to work well.

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尝试局部类固醇鼻准备或鼻内异丙托溴铵睡前。Try topical nasal steroid preparation or intranasal ipratropium bromide before bedtime.

从现在开始去氨加压素所有鼻腔用剂型都禁忌用于PNE。All intranasal formulations of desmopressin are now contraindicated for the treatment of PNE.

加水重建后，选择鼻粘膜给药途径以避免药物的首过效应。To avoid the extensive first-pass effect, intranasal administration is chose after reconstitution.

鼻内给予苯巴比妥的抗惊厥效能通过杏仁核点燃模型来测定。The anticonvulsant efficacy of intranasal phenobarbital was determined in the amygdala kindling model.

氯胺酮传统给药方式为静脉或肌肉注射，但是目前可考虑鼻内给药。Traditional administration has been the intravenous or intramuscular route, but consider intranasal now.

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本研究建立的离体牛嗅黏膜模型实验手段简便，适用于经鼻脑靶向给药系统的体外评价。The in vitro model would be useful for the evaluation of the intranasal delivery system for brain targeting.

观察布地奈德以鼻内雾化吸入的方式辅助治疗急性鼻-鼻窦炎的临床疗效。To observe the clinical efficacy of intranasal nebulized budesonide inhalation in 42 cases of acute sinusitis.

鼻内皮质类固醇可能是合并鼻炎及轻度气喘患者另一种有效的治疗。Intranasal corticosteroids may be a promising alternative treatment for patients with rhinitis and mild asthma.

目的研究褪黑激素鼻黏膜给药淀粉微球的制备工艺。Objective To investigate the preparing technique of melatonin starch microspheres for intranasal administration.

因此我们分析了苯巴比妥的鼻内给药能否成为一种有价值的治疗途径。Therefore we analyzed whether intranasal administration of phenobarbital may render a valuable therapeutic approach.

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GACVS审议了关于一种经鼻给药的新型流感疫苗的安全性问题。The Committee considered safety issues pertaining to a new generation influenza vaccine, administered by the intranasal route.

目的探讨鼻内窥镜下经前颅底进行前颅窝手术的可能性。Objective To explore the possibility of performing anterior cranial fossa surgery by an intranasal endoscope via the anterior skull base.

结论药代动力学和药效学结果证明，三七总皂苷鼻腔给药制剂具有很好的开发前景。Conclusion The results of pharmacokinetics and pharmacodynamics demonstrated that PNS intranasal preparation has a pretty prospect to develop.

本文综述鼻腔免疫应答的细胞和分子机理、抗原释放系统及佐剂等方面的最新研究进展。We summarize the recent advances of the cellular and molecular mechanism, the delivery system of antigen and adjuvant of intranasal immunization.

结论脑脊液鼻漏颅外进路修补疗效良好，特别是经鼻内窥镜修补。Conclusions The repair of CSF leak through transnasal extracranial approach can obtain better therapeutic results, especially through intranasal endoscopy.

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并与口服制剂、腹腔注射制剂、混悬液鼻粘膜给药制剂进行了比较。At the same time, oral and intraperitoneal preparations of NMD were also administrated to mouse and the effects were compared with that of intranasal route.

体内实验显示，尽管天坛株比神经毒性的WR株毒性弱很多，但天坛株仍保留相当的神经毒性，而且经鼻腔接种可引起小鼠体重严重下降。Moreover, VTT is much less virulent than vaccinia WR but remains neurovirulent in mice and causes significant body weight loss after intranasal inoculation.

结论滴鼻免疫对特异的黏膜免疫激发作用明显优于皮肤划痕，疫苗的滴鼻免疫途径较皮肤划痕有着明显的优势。Therefore, the intranasal route of immunization is a suitable route to induce mucosal immune responses after immunization with the DNA vaccine of Hantaan virus.