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高效液相色谱法测定马钱子碱的含量。The content of brucine was measured by HPLC.

目的考察马钱子碱在大鼠体内的药动学性质。OBJECTIVE To investigate pharmacokinetic properties of brucine in rats.

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方法考察不同给药途径对马钱子碱在大鼠体内药动学的影响。METHODS The effect of administration route on pharmacokinetics of brucine was studied in rats.

目的建立骨康片中士的宁和马钱子碱的含量测定方法。Objective To establish the analytical method of strychnine and brucine in Gukang tablet by TLC.

结论复方马钱子碱腹腔注射有明显的镇痛作用，且起效迅速，作用强而持久。Conclusion Compound brucine has remarkable analgesic effect with power potency and long duration.

建立测定通痹灵片中马钱子碱、士的宁含量的方法。To establish a method for the determination of brucine and strychnine contents in Tongbiling Tablet.

目的采用反相高效液相色谱法测定伸筋丹胶囊中士的宁和马钱子碱的含量。Objective To establish a RP-HPLC method for determination of strychnine and brucine in Shenjindan capsules.

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确认死者的胃内容、肝组织中的高含量马钱子碱而引起的中毒死亡。The high level of the brucine ingredients in the gastric content and the hepatic tissue is the cause of death.

结论给药途径是影响马钱子碱体内药动学性质的重要因素。CONCLUSION The administration route is the key factor which influences the pharmacokinetics of brucine in vivo.

成果江西改良炮制法炮制品中士的宁和马钱子碱的含量较低。ResultsThe contents of strychnine and brucine in the processed products with Jinngxi innovated method were lower.

建立了用高效液相色谱法同时测定制马钱子中士的宁和马钱子碱的含量。HPLC method has been developed for simultaneous determination of strychnine and brucine in the Strychnos pierriana A.

结果江西法炮制品及其改良法炮制品中士的宁和马钱子碱的含量较低。Result The contents of strychnine and brucine in the processed products of Jiangxi methods and innovated methods were low.

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结论马钱子超微粉碎并不会造成士的宁的损失，且可明显提高其溶出速度。Conclusion The dissolution velocity of brucine are greatly increased and there is not loss of the brucine in ultra-micro powder.

结论方法准确、简便、重现性好，同时可以定量测定骨康片中士的宁和马钱子碱含量，可作为该药的质量控制方法。Conclusion The strychnine and brucine in Gukang tablet were simultaneously detected by TLC. The method can use for controlling quality of the tablet.

由于马钱子碱和硝酸反应后生成的产物具有电化学活性，因此，可以微分脉冲极谱法对马钱子碱进行测定。The application of differential pulse polarography to brucine reaction product, having electroanalytical activity, with HNO_3 has been reported in this paper.

目的用HPLC法对马钱子的江西法炮制品及其改良法炮制品的水煎出物中士的宁和马钱子碱含量进行测定。Objective HPLC method was used to determine strychnine and brucine in the decoction of Semen Strychni and its processed products of Jiangxi methods and innovated methods.

本文提出了应用氧化铝薄层，分离番木鳖制剂中士的宁和马钱子碱的简单方法。A thin-layer chromatographic method is proposed for separation of strychnine and brucine in the Nux Vomica preparations such as extract, liquid extract, and tincture of Nux Vomica.

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目的评价和比较马钱子碱及其脂质体对移植性肿瘤模型荷瘤小鼠的肿瘤抑制作用和生存时间的影响。Objective To evaluate and compare the effects of brucine and its liposome on inhibiting transplanted tumor growth and prolonging their survival time in mice with transplanted tumor cells.

目的评价和比较马钱子碱及其脂质体对移植性肿瘤模型荷瘤小鼠的肿瘤抑制作用和生存时间的影响。Objective To evaluate and compare the effects of Brucine and Brucine liposome on restraining transplanted tumor growth, prolonging their survival time in mice with transplanted tumor cells.