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属于或与细胞的中心体有关。The entire cell aster with the exception of the centrosome.

因此，肿瘤细胞基因不稳定与中心体异常密切相关。Therefore, tumor cell gene instability and centrosome abnormalities are closely related to.

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极光激酶A参与中心体分离、成熟和纺锤体组装及稳定。Aurora A is involved in centrosome separation, maturation, and spindle assembly and stability.

事实上，在很多实体瘤中都发现过中心体连接和分离的机能失常。Malfunctions in centrosome cohesion and separation, in fact, have been seen in many solid tumors.

他们将染色体、着丝粒和中心体的起点连接起来。They form a connection between the starting point in the chromosomes, the kinetochore, and the centrosome.

中心体周期和细胞周期相互配合以保证遗传物质的精确分配。The coordination of the centrosome cycle and cell cycle ensures an accurate distribution of genetic material.

在除真菌以外的所有真核细胞中存在一种结构，在细胞分裂时可以形成纺锤体。Centrosome A structure found in all eukaryotic cells, except fungi, that forms the SPINDLE during cell division.

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现已发现了许多中心体蛋白及与中心体复制相关的蛋白激酶，调控着中心体复制的各个步骤。Many centrosome-related proteins and kinases have been found to regulate different steps of centrosome duplication.

这种停滞是暂时的，中心体取向被纠正后，细胞会重新进入细胞周期。The cell cycle arrest is transient, and GSCs appear to re-enter the cell cycle on correction of centrosome orientation.

扰乱中心体分裂的时空动态性会导致细胞分离中基因组的不稳定性。Perturbation of the spatiotemporal dynamics of centrosome splitting can lead to genomic instability during cell division.

随着研究的进展，人们不断认识到中心体的复杂功能及其重要性。With development of the research, the complicated function of centrosome and its im-portance have gradually been realized.

中心体异常扩增可作为一个客观的细胞形态学异常的指标，辅助宫颈癌前病变及宫颈鳞癌诊断。Centrosome amplification could be served as an alternative diagnostic indicator of dysplasia and cervical squamous cell cancer.

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中心体的正常复制对于细胞分裂时双极纺锤体的形成、染色体的正确分离是至关重要的。Centrosome duplication is a key requirement for bipolar spindle formation and correct segregation of chromosomes during cell division.

由此，科学家们证实这些检测点激酶同样存在于细胞中心体附近，并发挥着他们的作用。Accordingly, the researchers have proved that these checkpoint kinases also exist alongside the centrosome and perform their function there.

现就有关中心体异常在恶性肿瘤特别是膀胱移行细胞癌发生进展中的作用作一综述。The roles of centrosome abnormality in the origination and development of cancers, especially in bladder transitional cell carcinoma are reviewed.

它在细胞分裂之前复制，其中一个中心粒移向细胞的另一端，组织纺锤体和中心体。Prior to cell division it replicates and the sister centrioles move to opposite ends of the cell to lie within the spindle-organizing structure the centrosome.

中心体的发现和研究已经超过一世纪，但我们对其内部运作机制仍所知有限，科学家认为这项发现将有助于解释中心体的演化和功能。Relatively little is known about the inner workings of centrosomes even after a century of study, and the investigators suggest their discovery could explain centrosome evolution and function.

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综上所述，有丝分裂期CPAP的自身相互作用被磷酸化作用负调控，这对于中心体连接和分裂在细胞周期中的精确调控有重要作用。Collectively, these results demonstrate that negative regulation of CPAP self-interaction by mitotic phosphorylation is required for accurate centrosome cohesion and splitting during the cell cycle.

中心体异常与肿瘤发生的相关性已越来越受到人们的重视。More and more importance is attached to the correlation between centrosome abnormity and tumorigenesis, It refers to multiple genes abnormity, mainly separated into oncogene and tumor suppressor gene.