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建立了红曲霉真菌毒素桔霉素的HPLC检测方法。HPLC method of analysis of Monascus citrinin was established.

桔青霉素是能引起肾脏毒性的真菌毒素，并有致癌性。Citrinin is a mycotoxin which can induce renal dysfunction, and it is tumorigenic.

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随着温度升高，色素和桔霉素损失增大。The losses of pigment and citrinin were augmented with the increase of the temperature.

本发明涉及两种二聚桔霉素类化合物的制备方法和用途。The invention relates to a preparation method and a use of two dimer citrinin compounds.

本发明涉及两种三聚桔霉素类化合物的制备方法和用途。The invention relates to preparation methods and applications of two trimeric citrinin compounds.

本文从红曲的抑菌作用出发，重点研究了红曲中的橙色素和桔霉素。The dissertation focuses on the antibiotic substances produced by Monascus, orange pigment and Citrinin.

阐述了定性及定量测定红曲产品中桔霉素含量的几种方法。The methods for the determination of citrinin contents in Monascus products were described in this paper.

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红曲霉中桔霉素的发现使得我国的红曲产品的安全性引起争议。Accordingly, the discovery of citrinin in monascus brought tremendous dispute about the safety of red starter products.

初步总结了定性和定量测定高色价红曲米中桔霉素的方法。In this paper, we also summarize the methods of TLC and HPLC determination of citrinin for high color value red rice samples.

红曲霉在我国的应用源远流长，但桔霉素问题在一定程度上限制了红曲霉的深度开发。Monascus has been widely used for centuries in China, but the problem of citrinin restricts deep development to a certain extent.

此外，本压电免疫感测器具良好的专一性，在高浓度的赭麴毒素的存在下并不会产生显著的交叉反应。It was observed that the citrinin assay is specific, no significant cross reactivity was observed in the presence of ochratoxin A.

并提出了开发功能性红曲产品的发展方向，讨论了有关桔霉素的安全含量问题及红曲色素色价的测定方法。Developing trend of functional red koji, safe content of citrinin and determination of pigment concentration in red koji were discussed.

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桔霉素是一种真菌毒素，作用的靶器官是肾脏，可以致畸、诱发肿瘤、突变等。However citrinin produced in the growth process of monascus is a mycotoxin and will induce teratogenicity carcinogenicity and mutagencity.

根据国内外对桔霉素的最新研究报告，采用薄层层析法，对红曲中桔霉素的提取方法和展开剂分别进行研究。On the basis of the domestic and oversea up dated study reports, the extracting method and developer of Citrinin analysis inHongqu product have been researched.

通过对获得的5株红曲霉菌株的生物学特性进行研究，选出了一株生长速度快、产桔霉素低、产色能力强且为紫红色的优良菌株M2。Based on the research on biological characteristics of 5 Monascus strains, an excellent strain M2 with quick growth, low Citrinin and high Purpureous pigment was defined.

方法用高效液相色谱方法对采自市场或厂家送检的114个红曲产品进行了研究。Methods A total of 114 samples with either solid or liquid phases, collected from markets or delivered by the food production factories were analyzed by HPLC for citrinin.

以往的研究大多是希望通过发酵过程控制降低红曲产品中桔霉素，但实际上这条技术路线是行不通的。To reduce the concentration of citrinin in red yeast rice, many people want to solve this problem by controlling fermentation process. But in fact this technology doesn't work.

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红曲的药用价值和保健功能日益引人关注，然而红曲中桔霉素的存在严重制约着红曲产品的开发，如何降低红曲桔霉素的含量是一个迫切需要解决的问题。Pepole pay more attention to the medicinal value and health function of Monascus day by day, however, the existence of citrinin restricted the further development of Monascus products heavily.

变温培养时红曲霉产桔霉素量增加，恒温培养时色价高于变温培养时。The Monascus could produce more citrinin by fluctuation temperature culture, and the color value produced by constant temperature culture was higher than that by fluctuation temperature culture.